دفراسیروکس

DEFERASIROX

International non-proprietary name (INN):
DEFERASIROX


Chemical Abstract Index name:
[۴-[(۳Z,5E)-3,5-bis(6-oxo-1-cyclohexa-2,4- dienylidene)-1,2,4-triazolidin-1-yl]benzoic acid


CAS Registry No :
201530-41-8

Indication:
Deferasirox is an orally active iron chelator that is used in the management of chronic iron
overload due to blood transfusion

Structure

Physical form and appearance : A white to Cream powder, practically odorless

Physical state: Solid

Form: Powder

Molecular weight: 373.4 g/mol

Molecular formula: C21H15N3O4

Identification: HPLC

Assay (HPLC): 99-101 %w/w

Solubility: Inoluble in water, Very slightly soluble
in methanol, Soluble in aqueous alkali hydroxide (NaOH)

Storage: Keep container tightly closed and store
at room temperature.

Technical specification:
(HPLC): 99.5%

Related substance (HPLC)

Individual impurity ≤≤ ۰٫۵۰%,

Total impurities ≤۱٫۰۰%

Method: In-House method as per ICH


Guidelines :